Therefore, one should characterize microemulsion structures in detail for improving novel and effective techniques and applications. Characterization of microemulsions prepared using isopropyl pseudoternary phase diagram was used to define the microemulsion area. Design and characterization of microemulsion systems for naproxen. Progress in microemulsion characterization, current. The objective of the present study was to formulate and evaluate microemulsion systems for topical delivery of clotrimazole ctm. Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitatewaterbrij 97. The research interest is preparation and characterization of oilinwater and waterinoil emulsions. To improve the bioactivity and oral bioavailability of myricetin, a microemulsion formulation was successfully developed, which consisted of cremophor rh40 12%, tween 80 6%, transcutol hp 9%, wl 49 18%, and distilled water 55%.
The book also addresses characterization methods, including xray diffraction, transmission electron microscopy tem, light scattering, and smallangle neutron scattering. This research was aimed to formulate and characterize a microemolsion systems as a topical delivery system of naproxen for relief of symptoms of rheumatoid arthritis, osteoarthritis and treatment of dysmenorrheal. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. Thus, i would like to talk about what is emulsion, what are the main characteristics of emulsions, what are the existing methods for preparations of emulsions and how to make simple emulsions. Phase behaviour and characterization of microemulsion. The objective of this study was to develop an oral microemulsion formulation of the antitumor diterpenoid agent, ent11. This research was aimed to characterize microemulsion systems of isopropyl palmitate ipp, water, and 2. Characterization of microemulsions prepared using isopropyl palmitate with various surfactants and cosurfactants. At 45% wtwt surfactant system, microemulsions containing various ratios of water and ipp were prepared and identified by electrical conductivity.
How to clean them without loss of crystalline surface structure. The mean droplet size range of microemulsion formulation was in the range of 5. Mandal baroda college of pharmacy, vadodara, india. Five ctm microemulsion formulations m1m5 were prepared and. The process was optimized for the speed and time of stirring using ng microemulsion and results tabulated in table 5. A pseudoternary phase diagram was constructed using water titration method. Formulation of a new oilinwater ow microemulsion composed of castor oiltween 80ethanolphosphate buffer for heightening the lading capacity of an antiinflammatory drug feldene has been accomplished. With lower content of surfactants and higher stability after dilution and storage for 6 months, the optimized myricetin microemulsion myrme could. By using microemulsion, the cream was prepared for proving optimum structure for topical application. The microemulsion system thus, shows a structural change from oil continuous system to water continuous, which has higher viscosities than the former 34.
Pdf on jan 1, 2011, vipin saini and others published development and characterization of microemulsion based system of aceclofenac find, read and cite all the research you need on researchgate. Preparation and characterization of microemulsions of. Experimental and molecular dynamics characterization of dense microemulsion systems. Synthesis and characterization of mesoporous hydroxyapatite. Pseudoternary phase diagrams were constructed to identify the area of microemulsion existence. The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution. In chapter 1 a short introduction about the background, various aspects and applications. Various adsorbents were incorporated in the optimized liquid microemulsion to get solid microemulsion. View the article pdf and any associated supplements and figures for a period of 48 hours. Characterization and optimization of microemulsion and smedds akshay r. Therefore, it is a key to have an optimized microemulsion system to be made for uniformed and mesoporous hap. Microemulsion, palm oil, thermal analysis, tween 80, alcohol. Formulation, characterization, and in vitroex vivo evaluation of quercetinloaded microemulsion for topical application. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha.
Preparation and characterization of dexamethasone microemulsion based on pseudoternary phase diagram. Stability of microemulsion biofuels and their characterization. Progress in microemulsion characterization sciencedirect. Characterization of microemulsions prepared using isopropyl. Characterization of microemulsion structures in the.
Pdf development and characterization of microemulsion. Semicontinuous microemulsion polymerization pdf free. Pdf development and characterization of microemulsion based. The increased incidence of inflammatory diseases has. One of the most promising techniques for enhancement of transdermal permeation of drugs is microemulsion. The rapidly increasing number of applications for microemulsions has kept this relatively old topic still at the top point of research themes. In microemulsion systems, a variety of phases can exist in equilibrium with one another. Characterization and optimization of microemulsion and. Capmul mcm, captex 200, captex 300 and captex 355 were gift. Characterization and evaluation of an oral microemulsion.
Formulation and characterization of microemulsion based gel of antifungal drug download as pdf about authors. Characterization of microemulsion systems formed by a. These are selected as recommended by the camag tlc scanner iii manual. Preparation and characterization of oilinwater and water. Microemulsion based gel has been increased interest during recent years in the use of topical vehicle systems that could modify drug permeation through the skin.
Formulation, characterization, and clinical evaluation of. Particle size of the optimized microemulsion formulation was found to be 40. This book provides an assessment of some issues influencing the characteristics and performance of the microemulsions, as well as their main types of applications. The microemulsion was prepared using eucalyptus oil, tween 20 and methanol as the oil phase, surfactant and cosurfactant respectively. Experimental and molecular dynamics characterization of. Formulation and characterization of microemulsion system essay abstraction. Various characterization techniques for nanoemulsions include determination of entrapment efficiency, particle size, polydispersity index, zeta potential as well as characterization through differential scanning calorimetry, fouriertransform infrared spectroscopy and transmission electron microscopy. When gel and microemulsion are used in combined form and the dosage forms are referred as microemulsion based gel.
Review of nanoemulsion formulation and characterization. A microemulsion is basically characterized by analysing the phase behaviour of the system comprised of surfactant, cosurfactant, oil, and brine. Alkhatib biotechnology science and engineering program, university of alabama in huntsville, 35899 huntsville, al, usa. Largest microemulsion single phase region was found at s mix 2. Request permissions experimental and molecular dynamics characterization of dense microemulsion systems. We observed that the microemulsion area was wider at the phase diagram obtained with the higher purity lecithin. Naproxen is poorly water solubility and it is possible to increase its solubility by utilizing microemulsion systems. Darunavir was a gift sample from mylan laboratories ltd, hyderabad, india.
Apr 24, 2012 microemulsion synthesis, characterization of highly visible light responsive rare earth. The optimized microemulsion formulation was characterized for its refractive index, % transmittance, ph, viscosity, drug content and particle size. Microemulsion based gels have emerged as one of the most intresting topical drug delivery system as it has dual control release system i. Ethanol cosurfactant is expected to disorder the interfacial film gave extended microemulsion zones by destabilizing the liquid crystalline phase. Design and characterization of microemulsion systems for. Pseudoternary phase diagram was used to define the. Microemulsions have been characterized by determining water uptake capacity as well as paraffin oil uptake capacity by nephelometric titration. Formulation and characterization of microemulsion system abstract. Dec 22, 2004 processing and characterization of microemulsion. Aparna, prathima srinivas department of pharmaceutics, sri venkateshwara college of pharmacy, osmania university, madhapur, hyderabad500 081, andhra pradesh, india abstract. Progress in microemulsion characterization, current opinion. Characterization of microemulsion structures in the pseudoternary. Stability of microemulsion biofuels and their characterization ramchandra ram1, atul kumar shrivastava2, kunjbihari tiwari2 and d.
Characterization and evaluation of an oral microemulsion containing the antitumor diterpenoid compound ent11alphahydroxy15oxokaur16en19oicacid yingnian lu,1,2 kefeng wu,2 li li,2 yuhui he,2 liao cui,2 nianci liang,2 bozhong mu11department of chemistry, east china university of science and technology, shanghai, 2guangdong key laboratory for research and development of natural drugs. Formulation of a new oilinwater ow microemulsion composed of castor oiltween 80ethanolphosphate buffer for enhancing the loading capacity of an antiinflammatory drug piroxicam has been accomplished. Microemulsion synthesis, characterization of highly visible. Formulation consideration and characterization of microemulsion. Microemulsion formulations have distinct advantages over macroemulsion systems when delivered parenterally because of the fine particle microemulsion is cleared more slowly than the coarse particle emulsion and, therefore, have a longer residence time in the body. Formulation and characterization of microemulsion based. Semicontinuous ow microemulsion polymerization two approaches have been proposed to increase the polymer content using the excess surfactant remaining after the batch microemulsion polymerization. Kr patel, mr patel, formulation and characterization of microemulsion based gel of antifungal drug, pharmatutor, 2014, 22, 7989. The rheological studies showed that microemulsions followed a newtonian. Formulation, evaluation and characterization of periodontal microemulsion gel swaroopa.
Formulation, characterization, and in vitroex vivo. Formulation, evaluation and characterization of periodontal. This research was aimed to formulate and characterize a microemolsion systems as a topical delivery system of naproxen for relief of symptoms of rheumatoid. This article is from jundishapur journal of natural pharmaceutical products, volume 8. Topical and transdermal formulations and drug delivery systems, pp.
Pdf characterization of microemulsions prepared using. The objective of this study was to develop a green microemulsion with potential applications in the delivery system for oilsoluble solid active ingredients. Microemulsion was first introduced by hoar and schulman in 1943. Microemulsion systemtechnique has been recently applied in many fields such as oil production, coating, solvent extraction, cleansing agents, enzymecatalyzed reaction, preparation of nanoparticles, and porous or mesoporous materials. Both ow and wo microemulsion can be used for parenteral delivery. Characterization of microemulsion systems formed by a mixed 1,3. In many applications, they are required to accommodate functional additives such as drugs, polymers, and nanoparticles, which increase the complexity of the systems further. Theory and characterization methods the initial chapters cover theoretical aspects of microemulsion formulation, with particular focus on methodologies for preparation. Synthesis, characterization, and properties of amphiphilic. Preparation, optimization and characterization of microemulsions 170 titrated with the continuous phase. The external phase was added in a drop wise manner under vortex mixing. Dioxolane ethoxylateoctyl glucoside surfactant system mayson h.
The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. The results indicated that the developed microemulsion systems, especially me3, may be promising vehicles for the transdermal delivery of. Characterization of microemulsion structures in the pseudoternary phase. A microemulsion is an optically isotropic and thermodynamically stable colloidal dispersion, which possess spherical droplets either of wo or ow of the size pdf. Development and characterization of transdermal microemulsion gel for an antiviral drug brajesh kumar 1, sanjay kumar jain 1, sunil kumar prajapati 1, alok mahor 1 and ajay kumar 2 institute of pharmacy, bundelkhand university 1, jhansi up, india r. The influence of components on microemulsion formation, drug release capacity, permeation was studied by differential scanning calorimetry, xray diffraction, invitro release and exvivo drug permeation studies respectively. Experimental and molecular dynamics characterization of dense.
Progress in microemulsion characterization progress in microemulsion characterization acharya, durga p hartley, patrick g. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Feb 07, 20 naproxen is poorly water solubility and it is possible to increase its solubility by utilizing microemulsion systems. Characterization and optimization of microemulsion and smedds. Unlimited viewing of the articlechapter pdf and any associated supplements and figures. The solubility of ctm in various oils was determined to select the oil phase of the microemulsion systems. The best surfactant to cosurfactant ratio for microemulsion preparation was 3. Formulation and characterization of microemulsion based gel. Phase behaviour and characterization of microemulsion stabilized by a novel synthesized surfactant. Characterization and evaluation of an oral microemulsion containing the antitumor diterpenoid compound ent11alphahydroxy15oxokaur16en19oicacid yingnian lu,1,2 kefeng wu,2 li li,2 yuhui he,2 liao cui,2 nianci liang,2 bozhong mu11department of chemistry, east china university of science and technology, shanghai, 2guangdong key laboratory for research and development of natural.
A microemulsion was prepared using fatty acid methyl esters fames as the oil phase, a mixture of alkyl polyglycoside apg and alkylpolyethoxy carboxylates aec as the surfactant, and alkanol as a cosurfactant. Formulation and characterization of microemulsion system. We found that the extent of the microemulsion region depended upon both the purity of the lecithin and the surfactantcosurfactant scos mixing ratios k m. Semicontinuous microemulsion polymerization pdf free download.
Formulation consideration and characterization of microemulsion drug delivery system for transnasal administration of. Synthesis, characterization, and properties of amphiphilic block copolymer of acrylamide. Preparation and characterization of dexamethasone microemulsion. Electrochemical characterization of platinum nanoparticles prepared by microemulsion. Eskandar moghimipour, anayatollah salimi, soroosh eftekhari abstract purpose. Preparation and characterization of oilinwater and waterin. Download fulltext pdf development and in vitro characterization of microemulsions of isotretinoin article pdf available in acta pharmaceutica sciencia 552.
1341 222 1090 53 1516 1145 178 1251 1119 837 995 332 1212 875 849 352 1536 33 392 68 1492 1511 598 1394 734 1377 1451 833 1120 1311 856 734 1361 205 550 889 242 852 931